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Natural killer NK cells are an important effector cell type for adoptive cancer immunotherapy. Similar to T reductipn, NK cells can be modified to express chimeric antigen receptors CARs to enhance antitumor activity, but experience with CAR-engineered NK cells and their clinical development is still limited. Here, we redirected continuously expanding and clinically usable established human NK cells to the tumor-associated ErbB2 HER2 antigen.

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